Brand/Development name: Mesupron, Upamostat
Company(ies): Wilex
Principal Therapy Area: Cancer
£195 / $340 / €245
Online, PDF
WX-671 is an orally-available, second-generation serine protease inhibitor that is designed to target the urokinase plasminogen activator (uPA) system. Wilex' uPA programme is a promising new non-cytotoxic approach in cancer therapy to specifically block tumour metastasis in solid cancers. The uPA system has been shown to play a key role in tumour cell invasion and metastasis, as well as in primary tumour growth, of various solid tumours including breast (BC), ovarian, gastric, colon and pancreatic cancer.
WX-671 is a prodrug of Wilex' intravenous serine protease inhibitor, WX-UK1. The latter reduced the formation of metastases and inhibited primary tumour growth in various preclinical and Phase I trials. Orally-administered WX-671 is converted to WX-UK1 in the body and therefore, has the same mode of action.
final data expected in July 2011.
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