Brand/Development name: Folotyn
Company(ies): Allos Therapeutics
Principal Therapy Area: Cancer
Online, PDF
Pralatrexate injection is a folate analogue metabolic inhibitor that competitively inhibits dihydrofolate reductase, a small enzyme that plays a supporting, but essential role, in the building of DNA and other processes. Pralatrexate is also a competitive inhibitor for polyglutamylation by the enzyme, folylpolyglutamyl synthetase. This inhibition results in the depletion of thymidine and other biological molecules, the synthesis of which depends on single carbon transfer.
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