<p><h4>Evaluate the commercial prospects for:</h4>
Company(ies): Amgen, Takeda
Principal Therapy Area: Cancer
Ganitumab is a fully-human monoclonal antibody antagonist of insulin-like growth factor-1 (IGF-1) receptor, a protein important to the growth of tumours. Increased IGF-1 signalling mediates tumour proliferation, reduces apoptosis, and correlates with higher incidence and progression of common cancers. Ganitumab antibody binds to IGF-1 without cross-reacting with the closely-related insulin receptor.
Ganitumab exhibited broad antitumour activity in xenograft models, both as a monotherapy and when combined with chemotherapy.
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