Company(ies): Daiichi Sankyo
Principal Therapy Area: Cancer
Online, PDF
The humanised monoclonal antibody, tigatuzumab (CS-1008; TRA-8), targets the tenth member of the tumor necrosis factor receptor superfamily (TNFRSF10B), which is also known as death receptor 5 (DR5) or TRAIL receptor 2, and which is overexpressed on the cell surface of many types of tumours. Tigatuzumab induces apoptosis of these cells and accordingly, is being studied in a number of cancers with cells expressing DR5 on the cell surface.
The compound was discovered by joint research between Sankyo and the University of Alabama, and preclinical studies have shown an anticancer effect in vitro and in vivo.
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