Company(ies): Synta Pharmaceuticals
Principal Therapy Area: Cancer
£195 / $340 / €245
Online, PDF
STA-909 is a synthetic, orally-bioavailable heat shock protein 90 (Hsp90) inhibitor that is structurally unrelated to first-generation Hsp inhibitors, namely geldanamycin and its derivatives. Hsp90 is a molecular chaperone that facilitates the correct folding of specific signal transduction proteins involved in cell proliferation, including human epidermal growth factor receptor-2 (HER2), vascular endothelial growth factor (VEGF), Akt and Raf kinases. Inhibiting Hsp90 prevents the refolding of key oncogenic proteins, preventing cell proliferation and survival. STA-9090 has been shown preclinically to inhibit many of these critical oncogenic proteins such as HIF1alpha, Kit, Met, HER2, EGFr, Akt, CDK4, Bcr-abl, BRAF, RAF1 and WT1.
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